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Chem Res Toxicol 21:805812

Trends in endocrinology and metabolism: TEM

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In vitro studies in prostate cancer cells with PROTAC UBX-390 (DC 50 = 2.4 nM, D max = 96%) demonstrated that it has a prolonged degradation activity superior to that obtained with predecessor PROTACs, such as ARV-110 (DC 50 = 3.1 nM, D max = 96%) which is currently in clinical studies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 231.Tudor M., Jandric I., Marovic A., Gjurasin M., Perovic D., Radic B., Blagaic A.B., Kolenc D., Brcic L., Zarkovic K., et al
