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These properties allow non-covalent interactions to occur with Lys10 and Lys12 in the N -terminal domain, which translates into a reduction of -Syn aggregation and the disassembling of preformed fibrils, presumably stimulating the formation of off-pathway oligomers [306]

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Real-world mechanism validation examples Glaucoma neuroprotection case: 65-year-old with moderate glaucoma, pressure well-controlled at 14mmHg on drops but showing 2-3% yearly visual field loss

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