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Macrophages induce the expression of the neutrophil chemokine (C-X-C motif) ligand 8a (Cxcl8a) in cells under ERS, recruit neutrophils into islets thus promoting the loss of cells

Published online Mar 25, 2022

doi: 10.1016/j.jdermsci.2013.12.007

The context-dependent regulation of NRF2 creates therapeutic dilemmas: While NRF2 activation shows promise for treating neurodegenerative diseases by enhancing antioxidant defenses, its inhibition may be required in cancers where NRF2 hyperactivation promotes tumor survival and drug resistance