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In a recent metanalysis of 39 studies of functional connectivity during motor tasks, patients with PD consistently showed reduction in activation of the posterior putamen, cerebellum, primary motor cortex and supplementary motor area, but also increased activation to cortical regions connected to the anterior putamen 147

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The open-label study design used in the remaining three intervention studies left them at high risk of selection, performance and detection bias [46, 49, 65], however, all studies provided complete outcome data and full reporting of results