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Pathophysiology Excessive breakdown of heme occurs due to hemolysis, which can be caused by various hereditary and autoimmune diseases that result in deficient red blood cell membranes (such as hereditary spherocytosis), enzyme deficiencies (such asG6PD), and abnormalities in hemoglobin structure

Bruises typically fade within two weeks without treatment

Type I, II, and III IFNs are the three primary classes of IFNs

Neuropsychopharmacology 35, 19621972

Brain Behav Immun (2011) 25:3359.10.1016/j.bbi.2010.10.010 209 FelgerJCLotrichFE