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however, it declines with age [ 18 ]

Pathogenesis A spontaneous or treatment-associated proliferative collection of hepatocytes spanning several lobules and without evidence of prior hepatic damage

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This typically results in nutrient malabsorption along with a wide variety of symptoms, ranging from diarrhea and constipation to skin rashes and depression (Brown 2012

Notably, an important aspect to consider in the advancement of copper ionophores for clinical therapeutic applications is the notable impact that slight structural changes can exert on their properties and functions [16]