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41: 2304 Rizza V, Lorefice R, Rizza N, et al

These data suggest that administration of levocarnitine to healthy elderly subjects may result in reduction of total fat mass, and increase of total muscle mass, may be reduce fatigue and serum lipids

However, due to limited ocular penetration (~ 0.3%), high concentrations and frequent applications are required [112]

Then, a 2020 systematic review and meta-analysis of 37 randomized, controlled clinical trials found that l-carnitine supplementation provides a modest reducing effect on body weight, BMI and fat mass, especially among adults with overweight/obesity. While L-carnitine may work for some people, it shouldnt be considered a quick fix

Origlia N, Migliori M, Panichi V, Filippi C, Bertelli A, Carpi A, Giovannini L: Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity

For example, carnitine-modified drugs can effectively target OCTN2 transporters to improve drug bioavailability [182, 183]