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The most common risks are complications with anesthesia, infection, and stroke

Trial-product estimand

The average weight loss of 2-3 kg over 12 weeks, while statistically significant, is substantially less than results achieved with appetite-suppressing medications or intensive dietary interventions

It protects neurons from oxidative damage, supports mitochondrial function, and may reduce the risk of neurodegenerative diseases such as Alzheimers and Parkinsons

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After adjusting for sex and health status, the only significant relationships in the respiratory parameters, normalized to cell count, were a slight age-dependent increase in routine respiration (slope = 0.004, SD 0.002, P = 0.03) and ET capacity (slope = 0.026, SD 0.010, P = 0.01) in PBMCs (Fig