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Oral Dis 24:14841491 Ferreira LDS, Calderipe CB, Maass JB et al (2022) Oral pigmented lesions in syndromic individuals: a systematic review

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Epidemiological and clinical data indicate that MD adherence is beneficial in IBD: higher MD scores are linked to lower IBD incidence (especially CD) and to better disease outcomes, including reduced inflammatory markers, improved clinical scores and even lower mortality

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Brown or black pigmentation spreading from the nail bed, matrix and nail plate to the adjacent cuticle and proximal or lateral nail folds (Hutchinsons sign) is a crucial clinical clue to diagnose or exclude melanoma[78]