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10.1038/nrn2639 Nat

This review highlighted some of the pericyte metabolic pathways and how they are impacted by chronic hyperglycemia, leading to oxidative stress, AGE accumulation, inflammation, and mitochondrial dysfunction

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Bioavailability increased with longer post-dose fasting time, reaching a plateau around 1.4% at 120 min (Fig

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That drop apparently triggered a wide range of compensatory reactions: extra copies of mitochondrial complexes were created, Complex 1 activity skyrocketed, proton pump activity increased, as did enzymes that consumed oxygen