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2006 Mar;53(3):278-86

Clin Exp Reprod Med

The pathological process of cardiac remodeling, which involves alterations in the structure and function of the heart, is a major way that TMAO aggravates these effects [77]

However, certain conditions like pregnancy may result in increased excretion of L-carnitine, potentially increasing the risk for deficiency

In a model of lung injury induced by amethopterin, carnitine has shown therapeutic potential by reducing the activities of P53 and CD68 while increasing the activity of Bcl-2 [310]

Based on preclinical studies, it has been suggested that L-carnitine supplementation could limit the imbalance between protein anabolism (synthesis) and catabolism (degradation) that leads to skeletal muscle wasting (42)