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But mechanisms need clinical backup, and the evidence base for ergothioneine in skin has meaningfully expanded between 2023 and 2026

HES (for 10 days) to CIPN rats significantly reduced PTX-induced increases in MDA, NF-B, IL-1, TNF-, COX-2, nNOS, JAK2, STAT3, and GFAP levels with neuropathic pain and alleviated endoplasmic reticulum stress (ERS) [133]

2019 Sep;72:100767

So compared to the amount that we usually recommend

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2018;3:eaar6689