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doi: 10.1016/j.yexcr.2021.112768

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Since ATF3 is a bona fide substrate of E3 ligase MDM2, MDM2 is the only E3 ligase so far known to degrade ATF3 ( Strikingly, our data revealed that by binding with RING domain of MDM2, PXR decreased MDM2 protein expression, enhanced polyubiquitination of MDM2, and reduced MDM2 protein half-life ( Figure 5 )

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On the other hand, it must be stressed that the above values are averages and there might be significant spatial heterogeneity 57

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Reduced methylation has been associated with many conditions including dementia, Parkinson's disease, Autism, Chronic Fatigue Syndrome

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