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In parallel, dysfunction of cytoplasmic Pattern Recognition Receptors (PRRs) (e.g., retinoic acid-inducible gene I) impairs downstream type I interferon (IFN-I) signalling, resulting in diminished phagocytic capacity and blunted IFN-I responses [48]

This antioxidant action strengthens the skin barrier, protecting against environmental aggressors (Pickart et al., 2014)

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Plasmids and constructs Single guide RNAs (sgRNAs, Supplementary Table 2) were designed using the VBC score sgRNA prediction tool 82 and cloned into a lentiviral vector enabling expression of the sgRNA and IRFP670 (pLenti-hU6-sgRNA-PGK-IRFP670)

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