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[DOI] [PubMed] [Google Scholar] 25.Cannarella R., Crafa A., Barbagallo F., Mongio L.M., Condorelli R.A., Aversa A., Calogero A.E., La Vignera S

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343 Evexomostat (SDX-7320), which irreversibly binds METAP2 and regulates insulin, leptin, and adiponectin downstream, was one of the first drugs developed for cancer patients with metabolic complications

Interestingly, the inhibitor CPD-3B is virtually non-toxic to normal cells, while targeting not only GLS1 and GDH but also thioredoxin reductase (TrxR) and amidotransferase (GatCAB), resulting in the selective elimination of cancerous cells through a multifaceted mechanism

Sp 1 is a bond, -S-, -0-, -CO H-, - HCO-, ~ R'~, -N(CH 2 CH 2 )2N-, or -X- Ar Y (CH 2 ) n Z wherein X, Y, and Z are independently a bond, ~NR'~, S , or O , with the proviso that when n=0, then at least one of Y and Z must be a bond and Ar' is 1,2-, 1,3-, or 1,4-phenylene optionally substituted with one, two, or three groups of (C 1 -C 5 ) alkyl, (C1-C4) alkoxy, (C1-C4) thioalkoxy, halogen, nitro, -COOR', --CONHR', -(CH 2 )nCOOR, - -S(CH 2 ) n COOR, -O(CH 2 ) n CONHR', or -S(CH 2 ) n CONHR, with the proviso that when Alk' is a bond, Spi is a bond

Letter to the Editor Regarding The Landmark Series