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(1991) Nucleic Acids Res., 19: 4133-4137) or other vectors a mutant scFv gene repertoire can be created containing a V L gene of the prototypic M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91G, M25ADY93H, M25ADYHSRLF, M25 GRIT S GF YGD wtLC, M25FSITSGFYGDwtLC M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25ASIA, M25ASLF, M25ASwt, M25AVIA, M25AVLF, M25 ALIA, M25ALLF, M25wtIA, and/or M25wtLF antibody and a human V H gene repertoire (heavy chain shuffling)

Similarly, in a double-blind controlled trial among patients with obesity and COPD revealed that liraglutide resulted in increased FVC, carbon monoxide diffusion capacity (DLCO), and COPD assessment test (CAT) scores