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doi: 10.1016/j.ejim.2020.04.037

Glutathione in Health and Disease: Pharmacotherapeutic Issues

Not necessarily, but dosing frequency below once daily during the induction phase may reduce cumulative receptor activation and limit the magnitude of neuroplasticity changes
A cobalt (blue) salt block solves that problem quite easily

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While generally considered safe, high doses may affect the fetus or baby, so professional guidance is essential
