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Despite its therapeutic potential, butyrates clinical application is limited by its rapid absorption and metabolism, which result in low systemic availability and reduced efficacy in targeting specific tissues

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ROS-driven genetic alterations frequently affect key tumor suppressor and driver genes

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EMBO J 22: 19811989 Le Gall S, Neuhof A, Rapoport T (2004) The endoplasmic reticulum membrane is permeable to small molecules

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Kaja S, Payne AJ, Naumchuk Y, Koulen P

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