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These patterns were associated with patient symptom severity, low-FODMAP diet, and rifaximin exposure ( 2 S production pathways in IBS-D and palmitoleate biosynthesis in IBS-C) and interactions with diet and mood symptoms ( vs IBS^H) ( Table 3 Subtype-specific features and potential microbiome-targeted strategies

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The glutathione peroxidase pathway has been identified as a key antioxidant defense pathway triggering ferroptosis

All documented observations remain confined to investigational, laboratory-based examination and do not extend beyond structured research frameworks

Efforts to reduce lipid levels can even promote disease progression, as FAO may induce oxidative stress, exhausting antioxidant competences and promoting damage to cellular organelles and DNA