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There is some proof that the direct delivery of recombinant growth factors to the wound site could not be a practical therapeutic option, given the drawbacks of a short half-life of the growth factors, fast degradation, high cost, and unforeseeable harmful effects 13,14

Runx2/Osterix pathway: Upregulation of Runx2 (osteogenic differentiation core transcription factor) and Osterix expression induces directed differentiation of bone marrow mesenchymal stem cells into osteoblasts and increases new bone formation

Or maybe assisting transcription factors in accessing the DNA in the right places

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& Zhang, G

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