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If we give high doses of medication to lower the urate level, such as allopurinol, over time the tophus will gradually reabsorb

Melatonin Melatonin, a neuro-hormone produced in the pineal gland, may have a role in gallstone disease prevention or treatment due to its anti-inflammatory and free-radical-scavenging properties, as well as its beneficial effect on gallbladder muscle tone (Pozo 2010