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The ER reduction was suppressed by pretreatment of a glutathione synthesis inhibitor or by knockdown of ATF4, which induces glutathione-related genes

To evaluate the use of this enzyme in manipulating compartment-specific GSH pools, we transduced HEK 293T cells with either untargeted or mitochondria-targeted, human codon-optimized GshF , henceforth referred to respectively as GshF and mito-GshF , and confirmed their subcellular localization by cell fractionation (Fig

S23 A-B, C-D)

But dosages can vary depending on if youre treating severe, mild, or asymptomatic B12 deficiency

Another way is to mask the blood group antigens using biocompatible molecules, such as PEGylation or dopamine