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Upon contact and recognition, immature dendritic cells are activated, altering their morphology to activate both CD4 and CD8 T cells for a robust adaptive immune response (Liu and Cao, 2015)

An imbalance in gut microbiota is thought to drive the chronic inflammation associated with BD that is known to increase risk for both neuroprogression and medical comorbidities (Vaccariello and Nguyen, 2022)

Mannisto S, Smith-Warner SA, Spiegelman D, Albanes D, Anderson K, van den Brandt PA, Cerhan JR, Colditz G, Feskanich D, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Miller AB, Rohan TE, Virtamo J, Willett WC, Hunter DJ: Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies

Besides that, Bartons group found that electron transport happens over a long distance of DNA

However, only randomized controlled trials would be able to assess whether citicoline is protective against vascular damage and cognitive impairment in elderly adults with complex geriatric symptoms