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It was more effectively activated by elevated levels of GSH in H1299 lung cancer cells than that in normal lung fibroblasts WI38 cells, releasing reactive alkoxyamines to capture AP sites, blocking APE1 repair, and leading to lung cancer cell death in vitro

By deeply mining and analyzing these data, potential targets closely related to the development of pulmonary fibrosis can be identified, such as genes, proteins, and metabolites (Mann et al., 2021)

3.2 As an insulin secretion promoter and blood glucose regulator inhibitor inhibitor to regulate diabetic cognitive impairment Biopeptides play a crucial role in enhancing insulin secretion, which is a central component of glucose regulation mediated by the pancreas through insulin and glucagon release

Rapid plasma degradation and limited, variable BBB transport make systemic peripheral dosing of the parent peptide an inefficient route of exposure for any putative central target

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