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doi: 10.1186/1476-511X-3-15 65 SilvaR.TravassosL

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Downregulation of Opioid Receptors after Repeated Opioid Treatment Long-term repeated use of opioids, such as morphine, can lead to analgesic tolerance in patients, which is a major factor that reduces the opioid effect and is also one of the important reasons limiting application in various pain-related diseases [14,42,43,50]

For NRRL3357, 223 and 90 metabolites were differentially accumulated at 4 and 7 DAI, respectively, in response to stress

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