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S.EcksteinV.BogdahnU.et al (2013)

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Effect of epitalon on the lifespan increase in Drosophila melanogaster

The final dose shapes the endpoint, but titration determines whether that dose remains tolerable

Overall, multiple mechanisms including inflammation and reduced FA re-esterification likely explain the impaired buffering capacity in adipocytes during obesity that leads to the spillover of FAs, buildup of toxic lipid metabolites and allosteric regulators that suppress insulin action and increased hepatic glucose output, respectively (Figure 5)

Pregnant women who are vegetarians or vegans will also need to supplement, as a deficiency can greatly impact the fetus