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While DKO cells showed no detectable levels of mRNA for either IR or IGF1R, cells expressing normal IR and chimeric receptor IR/IGF1R had 14- and 10-fold higher receptor expression than endogenous IR expression in wild-type brown preadipocytes

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Oncogenic viral mechanisms and signaling pathways Oncogenic viruses play multifaceted roles in cancer by hijacking the host cellular machinery, disrupting critical regulatory pathways, and fostering a tumor-supportive microenvironment

Astrocytes dynamically control excitation and inhibition of neuronal networks Coordination of glutamatergic (mainly excitatory) and GABAergic (mainly inhibitory) inputs is of fundamental importance for the activity of neuronal networks and therefore required for normal cognitive function