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PMC 157943

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& Hettich, R

HIF-1 deletion led to the elimination of LSCs (61), in contrast, HIF-1 deletion promoted the conversion of pre-leukemic cells to LSCs, and HIF-1 knockout in MLL-AF9 mice showed LSCs increase and AML progression after chemotherapy (62)

Reference: arXiv preprint (not peer reviewed) Features & opinion A unique collection and collector Molecular palaeontologist Alexandra Morton-Hayward investigates why a small proportion of ancient brains somehow resist the decomposition process that begins to destroy most soft tissue within hours after death

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