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143 Physical instability and low lung deposition efficiency of nanoparticles, particle-particle interactions also hinder drug delivery to the lungs

They are often combined with traditional actives to create a synergic effect

That is, the main function attributed to the tight junction proteins is the gate and fence function, which allows the paracellular transport of some solutes and molecules but prevents the intramembrane transport of proteins, lipids, and microbial-derived peptides 25,26

LOOH can react with Fe 2+ and Fe 3+ to generate LO and LOO , respectively

Its deficiency is manifested through changes in the number and morphology of erythrocytes, leucocytes and platelets, and by neurological alterations owed to the progressive demineralisation of the nervous system (a consequence of defective myelin synthesis)

doi: 10.1007/s10048-012-0343-8 120