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Rifampicin has shown effectiveness in alleviating cholestatic pruritus but poses a hepatotoxicity risk in up to 13% of patients with prolonged use and has not been studied for pruritus in cirrhosis (4, 23)

Furthermore, intravenous glutathione (12 injections of 1,200 mg) showed no benefit for skin lightening compared to placebo in a Pakistani study (Zubair et al., J Pakistan Assoc Dermatol, 2016) [64]

J Biol Chem 283: 1785517863

C., Himi, E

There has been increasing popularity in Chinese medicine, especially since the 2015 Nobel Prize was awarded to Tu Youyou, who discovered that artemisinin from traditional Chinese medicine can treat malaria [9]

On the other hand, there might be some adverse effects of these synthetic nutraceuticals depending upon their manufacturing material