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Although the impact of PM on EMT has been investigated to some extent in recent studies, to the best of our knowledge, no study has investigated the effects of PM on MET, which is critical for wound healing, tissue repair, and regeneration ( It has been suggested that acute exposure to PMs, through increased production of cytokines such as IL-6 (115), STAT3 activation (117) and AhR activation (70), causes Notch1 inhibition (70) which leads to the differentiation of progenitor/stem cells into ciliated cells (117)

doi: 10.1080/14756366.2020.1867121 24 JeongE.MartinaJ

Additionally, mitochondrial dysfunction, retinal cell apoptosis, inflammation, and lipid peroxidation are key pathological processes associated with oxidative stress in DR

The disorder also exhibits extra-hematological features, such as leukocyte inclusions in neutrophils resembling Dhle bodies

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L., Jiang, S