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In vitro treatment of TMAO together with pro-inflammatory cytokine TNF- can increase the proliferation (detected by the cell-counting Kit-8 assay), migration (detected by the wound healing assay and the transwell assay), and invasion [detected by the expression levels of periostin, integrin-linked kinase (ILK)/RAC- serine/threonine-protein kinase (AKT1), and the mammalian target of rapamycin (mTOR)] of mouse liver cancer cell line Hepa16 cells and human liver cancer cell line Huh7 cells [64]

Altogether, these studies emphasise the relationship between increased BBB permeability and reduced vascular stability in the APOE4 genotype

PubMed Studies indicate sodium hyaluronate can be successfully formulated in hydrogel systems with complementary ingredients such as xanthan gum, demonstrating adequate physical and microbiological stability over extended storage periods