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Preclinical studies using optimized delivery systems have reported reductions of 2035% in visceral adipose tissue compared with administration of the non-encapsulated compound [124,131]

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This signaling role means MOTS-c influences gene expression patterns related to metabolism, inflammation, and cellular stress responses throughout the body

Pro-inflammatory cytokines are associated with several diseases such as renal disease, 3 obesity, 4 and inflammatory bowel disease