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et al., 2017), It also demethylates RAR in H460 and A549 lung cancer cells (Jiang et al., 2015), and downregulates MAT2A to reduce methylation in hematopoietic stem cells (Lu et al., 2021)

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A summary of the results of preclinical trials of GLP-1 on skeletal muscle are presented in Table 3

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Key neuropeptides affected include: Pro-opiomelanocortin (POMC) promotes satiety and increases energy expenditure Neuropeptide Y (NPY) and agouti-related peptide (AgRP) stimulate appetite and reduce energy expenditure Leptin resistance represents a significant challenge in obesity management
