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2021;116(3):249 -250
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Proteolytic digestions of Mpro revealed Cys300 as a primary target of glutathionylation, and experiments using a C300S Mpro mutant revealed that Cys300 is required for inhibition of activity upon Mpro glutathionylation
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These modifications stabilize the molecular structure, allowing it to mimic the amphipathic alpha-helix of the native hormone
