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European journal of nutrition

Safarinejad MR, et al

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16 Endometriosis, infections, and other acute and chronic inflammatory conditions can damage the integrity of the fallopian tubes, resulting in obstruction which can prevent normal transport of sperm and oocytes

Wnek agrees, and explains that "because of how deep these fat cells lie, it may be hard for caffeine in topical products to reach the target site to work." "Some benefits may be immediate, resulting from a temporary vasoconstriction of blood vessels, such as what occurs with caffeine, in which case using a cream in the days prior to a vacation may provide some instant benefit," said Dr