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This strategy is particularly compelling as the activity of these autoinhibitory factors is increased in obesity, hinting at an etiological role for them in leptin resistance [15, 48,49]
The highly reactive sulfhydryl group ( SH) of cysteine (Cys) acts like an antenna to attract reactive oxygen species (ROS) and free radicals [38]
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Various glutathione peroxidase mimetic compounds have been prepared and tested
