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Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis

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Given the FoxO1 ablation induced -cell dedifferentiation and caused hyperglycemia under physiologic stress 22 , we determined whether LOsG/ROS stresses decrease FoxO1 expression and thus induce -cell dedifferentiation
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doi: 10.1016/j.scienta.2021.110267 173

When copper metabolism is disrupted, excessive accumulation of copper generates reactive oxygen species (ROS) via the Fenton reaction (133)
