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Description
Being a water-soluble vitamin, they do not accumulate and can be removed by the urine

363 Recently, Zeldin and coworkers found that endothelial cells from CYP4F2 transgenic mouse exhibited a twofold increase in levels of 20-HETE, increased growth and tube formation with upregulation of VEGF and the prooxidant enzyme NADPH oxidase subunits (gp91phox and p47phox)
coli , where they conferred resistance to hydrophobic toxins like CCCP

The rationale is mechanistic extrapolation, not demonstrated synergy

Gough DR, Cotter TG
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