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Microglia, constantly surveying the brain environment, play crucial roles in immune surveillance and neuroprotection by phagocytosing neurons

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Studies indicate that activation of TLR2/3/4/5 triggers the NF-B/NLRP3 pathway and the PI3K/Akt/mTORC1 signaling pathway, leading to microglial activation, neuroinflammation, and neuronal damage (147, 148)

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Yuan X, Li N, Zhang M, Lu C, Du Z, Zhu W, et al

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