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Lipoic acid was found to upregulate the expression of -GCL and other antioxidant enzymes via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway (31, 33)

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Orthopaedic surgeons should lead clinical peptide research while using standard evidence alongside new sources to advance the field responsibly

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Given the availability of several comprehensive reviews and original studies addressing both sarcosine-derived and non-sarcosine-derived compounds, the current body of evidence indicates that GlyT1 inhibitors may exert therapeutically relevant effects in neurodegenerative diseases (Nishikawa et al