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For debilitating or severe pain, doctors may recommend stronger medication via a prescription
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BMC Cancer 23, 117
In rare cases, thiamine hypersensitivity, including urticaria, anaphylactoid reactions, collapse, and death have occurred, primarily following repeated parenteral administration
Furthermore, it was also noted that sometimes treatments would work well for a while, but then inexplicably stop working, so a recurring question was added to clarify whether benefits were sustained or temporary
