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FIGURE 1 2.2.1 Oxidative stress and renal diseases At physiological concentrations, reactive oxygen species (ROS) function as key signaling mediators, orchestrating a variety of critical cellular processes (Finkel, 2011)

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1 Introduction Acetaminophen (APAP), also called paracetamol, is one of the most widely used analgesic and antipyretic over-the-counter drugs in the world (Lee, 2008

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Eukaryotic cells have several antioxidant defense mechanisms such as enzymes and antioxidant biomolecules that maintain cellular balance between the generation of ROS and RNS, and their elimination [16]