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doi: 10.1210/jcem.77.6.7903313 93 SinhaDKBalasubramanianATatemAJRivera-MirabalJYuJKovacJet al

The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable