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This shows that hypertension leads to iron overload in the brain, and iron overload increases OS and lipid peroxidation, thereby causing ferroptosis (Yang et al., 2020) in neurons and ultimately leading to brain injury (Figure 2)

Rutherford G, Manning P, Newton JL

GLP-1MK-801 did not elicit pica behaviour in Sprague Dawley rats

Over the past two decades growing evidence has accumulated that targeting NAD + metabolism may provide therapeutic benefits and help treat metabolic disease and ageing 3

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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound)