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le Roux 2 , Adie Viljoen 1 Endocrinology and Metabolism 2024;39(1):12-22
Completion of adequate clinical trials will eventually make this determination
Slowing the ramp to the label cadence (2.5 mg start, 2.5 mg steps, four-week holds) dropped that to mid-single digits at every maintenance dose, at no cost to the 12-week result, and the dedicated slow-titration trial reached placebo range. Reaching 15 mg is not the problem
Bohula EA, Giugliano RP, Ruff CT, Kuder JF, Murphy SA, Antman EM, et al
Body composition changes remain minimal at this early stage
Cheng J, Arnold R
