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Over two days, 22 million gallons of raw human, industrial, residential and commercial waste poured into the river One of the most significant pollution events in Flints water history occurred in 1999

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However, there have been negative studies that used qualitative methods such as immunofluorescence or immunohistochemistry [70, 71]

Notably, effects were achieved via multiple routes of application including intragastric and local, suggesting broad applicability across experimental delivery methods

& Edwards, R