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Cancer Prevention Research

Targeting the apelin system for the treatment of cardiovascular diseases

[153] has elucidated that the downregulation of hepatic ACSL4 in hepatocytes within a murine model fed a hyperlipidemic diet results in a diminished accumulation of lipids and an exacerbation of insulin resistance
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The downstream effect of S1P1R blockade is the inhibition of the NF-B pathway [97]
