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Hepatocytes, myocytes, and brown adipocytes are characterized by particularly high metabolic activity (Frayn et al., 2006), as adipose, skeletal muscle, and particularly liver are among the top contributors to whole-body basal metabolic activity (Wang et al., 2012)

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6 In addition to inappropriate tissue and skeletal growth, acromegaly is characterised by perturbations of intermediary metabolism and diabetes

3.2.1 Hormonal abnormalities in the HPT axis The hypothalamus-pituitary-thyroid axis (HPT) is a hormone axis that regulates thyroid function by grading and feedback regulation of thyrotropin-releasing hormone (TRH), thyrotropin (TSH), thyroxine (T4), and triiodothyronine (T3)

D , In male mice, body mass in grams 14 and 35 d after diet initiation (two-way repeated measures ANOVA