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Glutaminase inhibitors inhibit pyrimidine synthesis and increase the ROS level in VHL-deficient RCC cells, and the PARP inhibitor olaparib and glutaminase inhibitors synergically inhibit the growth of these cells in vivo and in vitro (58)

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As previously reported (Vivarelli et al., 2024), the DNA was extracted from tissue biopsies by the use of AllPrep DNA/RNA Kit (QIAGEN, Venlo, Netherlands